Timely surgical cavity stereotactic radiosurgery (SRS) is an important adjuvant to brain metastasis resection, with earlier treatment associated with less frequent recurrence. The logistical complexity of treatment organization, however, has resulted in suboptimal start times postsurgically. We implemented a process improvement approach to reduce the time from surgery to adjuvant irradiation of resected brain metastases.

A multidisciplinary working group used process mapping to identify opportunities to reduce visits and shorten treatment times. The care delivery process was modified to streamline perioperative SRS preparation with (1) early patient identification, (2) preoperative intrateam communication, and (3) consolidation of required steps. Plan-Do-Study-Act cycles were used for process improvement. The surgery-to-SRS initiation time interval was the primary outcome. Secondary outcomes included the number of associated patient encounters.

After implementation, the median (interquartile range) intes critical.
Adjuvant SRS latency and treatment-associated encounters were significantly reduced after care-coordination implementation. This approach reduces patient and health care system burden and can be applied to other scenarios where early postoperative SRS administration is critical.Rational design of metal single-site embedded porous graphitic carbon nitride (P-g-C3N4) nanostructures exploiting maximum atom utilization is warranted to enhance the thermal CO oxidation (COOx) reaction. Herein, a facile, green, one-pot, and template-free approach is developed to fabricate the hierarchical porous P-g-C3N4-crumpled ultrathin nanosheets atomically doped with copper single atoms (Cu-P-g-C3N4). Mechanistically, the quick protonation of melamine and pyridine under acidic conditions induces deamination to form melem, which is polycondensed under heating. The interconnected pores, high surface area (240 m2g-1), and maximized exposed isolated Cu atomic active sites (1.8 wt %) coordinated with nitrogen atom P-g-C3N4 are the salient features of Cu- P-g-C3N4 that endowed complete conversion to CO2 at 184 °C. In contrast, P-g-C3N4 only converted 3.8% of CO even at 350 °C, implying the electronic effect of Cu single atoms. The abundant Cu-nitrogen moieties can drastically weaken the binding affinity of the CO-oxidation (COOx) intermediates and products, thus accelerating the reaction kinetics at a low temperature. This study may promote the fabrication of P-g-C3N4 doped with various single atoms for the oxidation of CO.There is a pressing need for new medicines to prevent and treat malaria. Most antimalarial drug discovery is reliant upon phenotypic screening. However, with the development of improved target validation strategies, target-focused approaches are now being utilized. Here, we describe the development of a toolkit to support the therapeutic exploitation of a promising target, lysyl tRNA synthetase (PfKRS). The toolkit includes resistant mutants to probe resistance mechanisms and on-target engagement for specific chemotypes; a hybrid KRS protein capable of producing crystals suitable for ligand soaking, thus providing high-resolution structural information to guide compound optimization; chemical probes to facilitate pulldown studies aimed at revealing the full range of specifically interacting proteins and thermal proteome profiling (TPP); as well as streamlined isothermal TPP methods to provide unbiased confirmation of on-target engagement within a biologically relevant milieu. This combination of tools and methodologies acts as a template for the development of future target-enabling packages.
Rectal cancer patients often face complex surgical treatment decisions, but there are few available tools to aid in decision-making.

We aimed to identify content and delivery preferences of rectal cancer patients and colorectal surgeons to guide future surgical decision aid creation.

Qualitative study inductive thematic analysis of semi-structured interviews.

In-person and phone interviews.

We purposively sampled 15 rectal cancer survivors based on demographics and surgery type. Five caregivers also participated. We purposively selected 10 surgeons based on practice type and years of experience.

Semi-structured interviews.

Major and minor themes for survivors and surgeons with thematic saturation.

Interviews were a median of 61 minutes (41-93) for patients and 35 minutes (25-59) for surgeons. Nine survivors were younger than 65 years; 7 were female. Surgeons had been practicing for a mean of 10 years (SD 7.4), with 7 in academic and 3 in private settings. Participating survivors and surgeons wsimple, comprensible, visualmente atractiva, interactiva, corta y en múltiples formatos.LIMITACIONESLos resultados pueden no ser generalizables debido al sesgo de selección de los participantes.CONCLUSIÓNLos sobrevivientes de cáncer rectal, sus cuidadores y los cirujanos colorrectales querían una herramienta de apoyo educativo que cubriera las necesidades educativas sustanciales a lo largo del tratamiento de la enfermedad en lugar de una ayuda para la decisión quirúrgica que se centre solo en una opción quirúrgica discreta. Consulte Video Resumen en http//links.lww.com/DCR/C20 . (Traducción-Dr. Yolanda Colorado ).Near-infrared (NIR)-emitting molecules are promising candidates for biological sensing and imaging applications; however, many NIR dyes are large conjugated systems which frequently have issues with stability, solubility, and tunability. Here, we report a novel class of compact and tunable fluorescent diradicaloid complexes which are air-, water-, light-, and temperature-stable. These properties arise from a compressed π manifold which promotes an intense ligand-centered π-π transition in the NIR II (1000-1700 nm) region and which subsequently emits at ∼1200 nm. buy LXH254 This emission is among the brightest known for monomolecular lumiphores with deep NIR II (>1100 nm) emission, nearly an order of magnitude brighter than the commercially available NIR II dye IR 26. Furthermore, this fluorescence is electrochemically sensitive, with efficient switching upon addition of redox agents. The brightness, stability, and modularity of this system distinguish it as a promising candidate for the development of new technologies built around NIR emission.The exciting success of NBTXR3 in the clinic has triggered a tumult of activities in the design and development of hafnium-based nanoparticles. However, due to the concerns of nondegradation and limited functions, the biomedical applications of Hf-based nanoparticles mainly focus on tumors. Herein, tannic acid capped hafnium disulfide (HfS2@TA) nanosheets, a 2D atomic crystal of hafnium-based materials prepared by liquid-phase exfoliation, were explored as high-performance anti-inflammatory nanoagents for the targeted therapy of inflammatory bowel disease (IBD). Benefiting from the transformation of the S2-/S6+ valence state and huge specific surface area, the obtained HfS2@TA nanosheets were not only capable of effectively eliminating reactive oxygen species/reactive nitrogen species and downregulating pro-inflammatory factors but also could be excreted via kidney and hepatointestinal systems. Unexpectedly, HfS2@TA maintained excellent targeting capability to an inflamed colon even in the harsh digestive tract environment, mainly attributed to the electrostatic interactions between negatively charged tannic acid and positively charged inflamed epithelium. Encouragingly, upon oral or intravenous administration, HfS2@TA quickly inhibited inflammation and repaired the intestinal mucosa barrier in both dextran sodium sulfate and 2,4,6-trinitrobenzenesulfonic acid induced IBD models. This work demonstrated that ultrathin HfS2@TA atomic crystals with enhanced colon accumulation were promising for the targeted therapy of IBD.
To analyze the accuracy of planned tooth movements of torque, tip, rotations, and transverse width values with lingual straight-wire technique.

40 Caucasian subjects with mean age of 23.9 years, consecutively treated in private practice with a lingual straight-wire appliance (STb, Ormco, Glendora, Calif) were evaluated. Maxillary and mandibular dental casts were taken before treatment (T0), in the setup (T1), and at the end of treatment (T2) and scanned with an intraoral 3D scanner Carestream CS 3600 (Carestream Dental, Atlanta, GA). Virtual models at the three time points were superimposed on T1 using 3D software, and the coordinates were exported as a set of x, y, and z values. Angular and linear measurements were analyzed to measure torque, tip, rotation movements, and transverse intra-arch widths. Changes among the three time points were analyzed with Friedman's nonparametric test.

A general increase in torque was recorded in the setup and in the final result, except for the maxillary molars. Torque, tip, and rotation movement mean accuracy was ≥84% for incisors, canines, and premolars. A general increase in transverse width was measured in the setup and in the final models, except for the upper second molars, which showed reduced transverse width during treatment.

The movements planned in the setup to obtain the ideal torque, tip, and rotations actually occurred, except for second molars, which showed less accuracy. Planned expansion of the arches occurred only partially.
The movements planned in the setup to obtain the ideal torque, tip, and rotations actually occurred, except for second molars, which showed less accuracy. Planned expansion of the arches occurred only partially.Space charge transfer is crucial for an efficient electrocatalytic process, especially for narrow-band-gap metal sulfides/selenides. Herein, we designed and synthesized a core-shell structure which is an ultrathin MoSe2 nanosheet coated CuS hollow nanoboxes (CuS@MoSe2) to form an open p-n junction structure. The space charge effect in the p-n junction region will greatly improve electron mass transfer and conduction, and also have abundant active interfaces. It was used as a bifunctional electrocatalyst for water oxidation at a wide pH range. It exhibits a low overpotential of 49 mV for the HER and 236 mV for the OER at a current density of 10 mA·cm-2 in acidic pH, 72 mV for the HER and 219 mV at 10 mA·cm-2 for the OER in alkaline pH, and 62 mV for the HER and 230 mV at 10 mA·cm-2 for the OER under neutral conditions. The experimental results and density functional theory calculations testify that the p-n junction in CuS@MoSe2 designed and synthesized has a strong space charge region with a synergistic effect. The built-in field can boost the electron transport during the electrocatalytic process and can stabilize the charged active center of the p-n junction. This will be beneficial to improve the electrocatalytic performance. This work provides the understanding of semiconductor heterojunction applications and regulating the electronic structure of active sites.In this conceptual article, we assert that psychology should be transformed to adopt the explicit goal of working toward the liberation of people oppressed by society rather than striving for mere equality. To achieve such a transformation, it is necessary to reenvision graduate training in psychology. Graduate training in psychology is an important vehicle by which psychologists can become prepared to use research and practice to eradicate inequities in society. Therefore, we propose six pillars for liberation-focused graduate training in psychology critical unlearning/unknowing, cooperative modes of production, prioritizing indigenous knowledge, embedded interdependence, systems-level action, and prioritizing members of oppressed groups. Although this conceptualization may engender resistance, we argue that there are many potential pathways by which graduate training may use liberation psychology to work equitably with oppressed groups to seek justice.buy LXH254