When deciding between .NET Core and Node.js for a project, it's essential to consider the specific requirements, strengths, and use cases of each technology. Both have their own advantages and can be optimal for different scenarios.

Overview of .NET Core
.NET Core is a cross-platform, high-performance framework developed by Microsoft for building modern, cloud-based, and internet-connected applications. It supports multiple programming languages, including C#, F#, and Visual Basic.

Overview of Node.js
Node.js is a JavaScript runtime built on Chrome's V8 JavaScript engine. It is designed to build scalable network applications, and it uses an event-driven, non-blocking I/O model, making it lightweight and efficient.