9 ± 64.0 min and 200 (50-800) ml compared to 176.3 ± 73.8 min and 50 (50-400) ml for RN. There was one operative conversion (7.7%) to an open approach in the PN group. Length of hospital stay postoperatively averaged 1.9 ± 1.3 days and 3.3 ± 1.2 days for patients undergoing partial and radical nephrectomy, respectively. SP partial and radical nephrectomies through transperitoneal and retroperitoneal approaches appear to be feasible surgical techniques in the management of cortical renal masses. Off-clamp PN is also a feasible approach using the SP system. However, further study is needed to establish its safety and use in renal surgery across multiple institutions and larger patient cohorts.AIM Canagliflozin (CFZ), a novel SGLT II antagonist, exhibits erratic absorption after oral administration. The current study entails development and evaluation of spray dried lipid based formulation (solid SMEDDS) for enhancing oral bioavailability and anti-diabetic activity of CFZ. METHODS Solid SMEDDS developed through spray drying containing Neusilin US2 as an adsorbent. The formed solid SMEDDS were characterized for physicochemical and solid state attributes. Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) were used to confirm the spherical morphology. In vitro dissolution, ex vivo permeability and in vivo pharmacokinetic studies were conducted to determine the release rate, permeation rate and absorption profile of CFZ, respectively. Pharmacodynamic studies were done as per standard protocols. RESULTS The optimized solid SMEDDS exhibited acceptable practical yield and flow properties and is vouched with enhanced amorphization, nanoparticulate distribution and acceptable drulipid based oral delivery a novel paradigm.Zinc plays a major role in skin integrity, which can be affected by dromedary camels' hard life conditions. Deficiencies in some trace elements especially in zinc can explain susceptibility of this species to skin diseases. Compared with ruminants, camel is already known for his relatively low zincemia. In order to assess dromedary camels' skin zinc content, the present study was carried out in several provinces located in the south of Morocco where camel skin diseases are commonly observed. Zinc content in dromedary camel skin was determined using for the first time laser-induced breakdown spectroscopy (LIBS), method considered so far quick and simple with few or no sample processing. Collected data showed that zinc skin contents ranged between 115 ± 60 (for external side) and 94 ± 82 ppm (for internal side) with significant variability according to animals and to skin layers (external side versus internal side). Zinc skin content decreased from external to internal layers. Such preliminary results could be used to compare skin zinc nutritional level in healthy camels with those affected by skin diseases.In this study, a simple, green, and cheap analytical procedure based on heat-induced deep eutectic solvent microextraction (HI-DES-ME) coupled with flame atomic absorption spectrometer (FAAS) was developed for the determination of Pb(II) and Cd(II) in vegetables. After the preliminary experiment, response surface methodology (RMS) based on central composite design (CCD) was used for the optimization of critical factors such as pH of sample solution, amount of extraction solvent, temperature, and amount of ligand. Microwave step was applied for the digestion of vegetable samples. Under optimum conditions obtained by the CCD, calibration graphs for Pb(II) and Cd(II) were linear in the concentration range of 0.5-250 and 1.0-300 ng mL-1, respectively. Limits of detection (LODs) and sensitivity enhancement factor (SIFs) were found in the range of 0.17-0.35 ng mL-1 and 93-67 ng mL-1, respectively. Relative standard deviations (N = 10, RSDs%) for Pb(II) (10 ng mL-1) and Cd(II) (50 ng mL-1) were 3.7% and 2.3%, respectively. In order to validate the proposed method, certified reference material (CRM) and spiked samples were used. Experimental results showed that there was no significant difference between the obtained and certified values. Then, the proposed method was successfully applied for the preconcentration and determination of Pb(II) and Cd(II) in different vegetables.Hexavalent chromium, a well-known environmental toxicant, adversely affects female reproduction and results in abnormal implantation, fetal resorption, and reduction in litter size. Uterine myogenic activity is under control of number of receptors and ion channels, and it regulates fetal-implantation and feto-maternal communication. Despite several known adverse effects of chromium on female reproduction, direct action of chromium on myometrial activity is yet to be understood. In the present study, the effect of in vitro exposure of hexavalent chromium (Cr-VI) on the myogenic activity of isolated myometrial strips of rats was evaluated after mounting the tissue in thermostatically (37 ± 0.5 °C) controlled organ bath under a resting tension of 1 g. Chromium produced concentration-dependent (0.1 nM-0.1 mM) inhibitory effect on myometrial activity. Following pre-treatment of the myometrial strips with glibenclamide (a KATP channel blocker) and 4-aminopyridine (a Kv channel blocker), the concentration-response catory mechanism, inhibitory mechanism.The management of a tracheal bronchus in lung transplantation is poorly studied and ill-defined. We report a case of lung transplantation performed using a donor right lung graft with an apical tracheal bronchus and propose a novel anastomosis technique for this procedure. The neo-upper lobe bronchus created by suturing the apical tracheal bronchus and the upper lobe bronchus of the donor was anastomosed to the upper lobe bronchus of the recipient in a double-barrel fashion. A follow-up at 19 months demonstrated no stenosis of the anastomosis. The advantages and potential disadvantages of this procedure are discussed.OBJECTIVE We evaluated beating heart thoracic aortic surgery (BHTAS) using selective myocardial perfusion (SMP) in patients with aortic anomalies with complex surgical needs. METHODS Between 2012 and 2018, 27 infants with aortic anomalies underwent BHTAS using SMP. RESULTS Median body weight was 3.5 kg (range 2.6-5.2). In total, 15 cases of aortic coarctation, 7 cases of hypoplastic left heart syndrome, and 5 cases of interrupted aortic arch were included. Androgen Receptor activity inhibition An extended aortic arch anastomosis maneuver was used in 7 cases and aortic arch reconstruction compensated with an autologous pericardium patch was used in 6 cases. A Norwood-type procedure was used in 11 cases. The median Aristotle comprehensive score was 13.9 (7.0-20.0). BHTAS cases were not inferior in postoperative CK-MB/CK ratio (12.4 ± 2.8 in BHTAS vs 13.9 ± 3.6 in CTAS, p = 0.09), and there were no instances of myocardial ischemia. Two late deaths occurred due to shunt obstruction (n = 1) and valve malfunction (n = 1). Freedom from aortic reintervention was not inferior to conventional thoracic aortic surgery.Androgen Receptor activity inhibition